Designer dogs But these high-priced “designer dogs” are also increasingly exploited by abusive breeders at puppy mills and unscrupulous sellers, leading to more sick puppies and unhappy owners, according to the Humane Society of the United States. Made fashionable by celebrities like Jake Gyllenhaal and Jessica Simpson, hybrid puppies – the offspring of two purebreds – often go for more money than purebreds, which can range from $200 to $2,000 per dog. Puppies bought from pet stores or Internet breeders are much more likely to have been born in a puppy mill and to therefore develop health problems, said Kathleen Summers, deputy director of the society's Stop Puppy Mills campaign. The Humane Society defines a puppy mill as any operation – licensed or unlicensed – where animals are continually confined, kept solely for breeding and socially or physically neglected.

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